HitPredict

Interactor 1: CDC7 (O00311)
Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)
Gene: CDC7

Interactor 2: MCM7 (P33993)
DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)
Gene: MCM7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	22540012, 12614612, 10846177
Identification Methods	enzymatic study, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000727 - double-strand break repair via break-induced replication GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 574 Hs			1 719
+	Xl
		879180 Q9PWM7_XENLA (38-572): 2.37e-139: 414: 56.90		MCM2_XENLA (8-690): 0: 646: 28.10
+	Hs
		125851 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM5_HUMAN (6-716): 0: 682: 27.61
+	Hs
		125859 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM2_HUMAN (8-690): 0: 643: 28.13
+	Hs
		125850 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM4_HUMAN (5-700): 0: 636: 31.52
+	Dm
		832234 Q9W3Y1_DROME (39-570): 1.13e-102: 327: 32.08		MCM2_DROME (6-688): 0: 640: 28.45
+	Hs
		125886 CDC7_HUMAN (1-574): 1.17e-106: 333: 100.00		MCM6_HUMAN (3-715): 0: 623: 28.05
+	Dm
		1099480 Q9W3Y1_DROME (39-570): 1.13e-102: 327: 32.08		MCM4_DROME (5-714): 0: 624: 29.95
+	Hs
		835755 GSK3B_HUMAN (9-376): 3.67e-74: 244: 16.67		MCM6_HUMAN (3-715): 0: 623: 28.05
+	Hs
		625168 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM7_HUMAN (1-719): 0: 786: 100.00
+	Sc
		412530 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM5_YEAST (5-716): 0: 666: 27.77
+	Dm
		1276831 Q94533_DROME (360-567): 6.19e-11: 66.8: 14.90		MCM7_DROME (1-719): 0: 733: 67.36
+	Sc
		412532 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM4_YEAST (7-703): 0: 658: 29.69
+	Sc
		412549 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM7_YEAST (2-719): 0: 643: 45.41
+	Sp
		772833 HSK1_SCHPO (317-569): 1.6e-34: 138: 26.09		MCM2_SCHPO (3-666): 0: 622: 30.42
+	Sc
		412576 CDC7_YEAST (356-573): 1.93e-35: 141: 25.45		MCM6_YEAST (9-704): 0: 616: 29.69
+	Sp
		667322 HSK1_SCHPO (317-569): 1.6e-34: 138: 26.09		MCM4_SCHPO (7-691): 0: 609: 30.26
+	Hs
		625235 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM2_HUMAN (8-690): 0: 643: 28.13
+	Hs
		625167 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM4_HUMAN (5-700): 0: 636: 31.52
+	Hs
		625435 CDK2_HUMAN (378-525): 4.27e-13: 72: 15.33		MCM6_HUMAN (3-715): 0: 623: 28.05