HitPredict

Interactor 1: Q8WNW7 (Q8WNW7)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha)
Gene: NFKBIA

Interactor 2: IKKB (Q95KV0)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12459277
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Bt			1 756
+	Mm
		291486 IKBA_MOUSE (1-314): 2.38e-72: 227: 92.68		IKKB_MOUSE (1-755): 0: 629: 90.07
+	Hs
		158400 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKB_HUMAN (1-756): 0: 622: 93.25
+	Hs
		121546 IKBE_HUMAN (70-312): 3.07e-70: 227: 37.25		IKKB_HUMAN (1-756): 0: 622: 93.25
+	Hs
		158446 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKB_HUMAN (1-756): 0: 622: 93.25
+	Hs
		158478 IKBB_HUMAN (70-311): 2.11e-58: 193: 30.74		IKKB_HUMAN (1-756): 0: 622: 93.25
+	Bt
		1259267 Q8WNW7_BOVIN (1-314): 1.9e-75: 235: 100.00		IKKA_BOVIN (1-742): 2.33e-170: 509: 48.93
+	Hs
		167475 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKA_HUMAN (1-742): 8.96e-170: 508: 49.40
+	Hs
		121549 IKBE_HUMAN (70-312): 3.07e-70: 227: 37.25		IKKA_HUMAN (1-742): 8.96e-170: 508: 49.40
+	Hs
		167522 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKA_HUMAN (1-742): 8.96e-170: 508: 49.40
+	Hs
		167551 IKBB_HUMAN (70-311): 2.11e-58: 193: 30.74		IKKA_HUMAN (1-742): 8.96e-170: 508: 49.40
+	Hs
		167471 BCL3_HUMAN (6-234): 6.21e-35: 133: 24.78		IKKA_HUMAN (1-742): 8.96e-170: 508: 49.40
+	Hs
		639818 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		TBK1_HUMAN (15-725): 2.65e-128: 400: 18.60
+	Hs
		961442 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		TBK1_HUMAN (15-725): 2.65e-128: 400: 18.60
+	Hs
		647851 DAPK1_HUMAN (1-173): 3.75e-36: 139: 15.39		MARK3_HUMAN (8-728): 1.66e-143: 440: 16.87
+	Hs
		862065 DAPK1_HUMAN (1-173): 3.75e-36: 139: 15.39		MARK2_HUMAN (2-728): 4.69e-142: 438: 16.91
+	Hs
		862115 DAPK1_HUMAN (1-173): 3.75e-36: 139: 15.39		MARK1_HUMAN (3-728): 6.49e-140: 433: 16.87
+	Hs
		639745 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKE_HUMAN (15-382): 2.63e-103: 334: 28.27
+	Hs
		961387 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKE_HUMAN (15-382): 2.63e-103: 334: 28.27
+	Hs
		1206082 MIB1_HUMAN (81-304): 5.45e-37: 142: 17.18		TBK1_HUMAN (15-725): 2.65e-128: 400: 18.60
+	Mm
		1193400 MIB1_MOUSE (81-304): 3.72e-37: 142: 17.18		TBK1_MOUSE (15-725): 8.07e-127: 396: 18.60