HitPredict

Interactor 1: Q8WNW7 (Q8WNW7)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha)
Gene: NFKBIA

Interactor 2: IKKA (Q95KV1)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (EC 2.7.11.10) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)
Gene: CHUK

Species: Bos taurus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12459277
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 314 Bt			1 740
+	Bt
		1259266 Q8WNW7_BOVIN (1-314): 1.9e-75: 235: 100.00		IKKB_BOVIN (1-737): 0: 597: 49.53
+	Hs
		158400 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKB_HUMAN (1-738): 0: 594: 50.40
+	Hs
		121546 IKBE_HUMAN (70-312): 3.07e-70: 227: 37.25		IKKB_HUMAN (1-738): 0: 594: 50.40
+	Mm
		291486 IKBA_MOUSE (1-314): 2.38e-72: 227: 92.68		IKKB_MOUSE (1-738): 0: 593: 48.66
+	Hs
		167475 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKA_HUMAN (1-740): 0: 585: 96.38
+	Hs
		121549 IKBE_HUMAN (70-312): 3.07e-70: 227: 37.25		IKKA_HUMAN (1-740): 0: 585: 96.38
+	Hs
		158446 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKB_HUMAN (1-738): 0: 594: 50.40
+	Hs
		167522 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKA_HUMAN (1-740): 0: 585: 96.38
+	Hs
		158478 IKBB_HUMAN (70-311): 2.11e-58: 193: 30.74		IKKB_HUMAN (1-738): 0: 594: 50.40
+	Hs
		167551 IKBB_HUMAN (70-311): 2.11e-58: 193: 30.74		IKKA_HUMAN (1-740): 0: 585: 96.38
+	Hs
		167471 BCL3_HUMAN (6-234): 6.21e-35: 133: 24.78		IKKA_HUMAN (1-740): 0: 585: 96.38
+	Mm
		291461 IKBB_MOUSE (70-287): 1.1e-27: 112: 33.98		IKKB_MOUSE (1-738): 0: 593: 48.66
+	Hs
		639818 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		TBK1_HUMAN (15-721): 1.05e-127: 398: 19.27
+	Hs
		961442 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		TBK1_HUMAN (15-721): 1.05e-127: 398: 19.27
+	Hs
		639745 IKBA_HUMAN (1-314): 8.1e-73: 228: 93.69		IKKE_HUMAN (15-729): 6.73e-118: 372: 19.13
+	Hs
		961387 NFKB2_HUMAN (55-294): 1e-61: 212: 32.93		IKKE_HUMAN (15-729): 6.73e-118: 372: 19.13
+	Hs
		862065 DAPK1_HUMAN (1-173): 3.75e-36: 139: 15.39		MARK2_HUMAN (2-722): 2.56e-129: 404: 16.62
+	Hs
		1206082 MIB1_HUMAN (81-304): 5.45e-37: 142: 17.18		TBK1_HUMAN (15-721): 1.05e-127: 398: 19.27
+	Mm
		1193400 MIB1_MOUSE (81-304): 3.72e-37: 142: 17.18		TBK1_MOUSE (15-721): 2.67e-127: 397: 19.41
+	Hs
		862115 DAPK1_HUMAN (1-173): 3.75e-36: 139: 15.39		MARK1_HUMAN (13-221): 1.19e-24: 112: 34.11