HitPredict

Interactor 1: NET5 (Q8WTR8)
Netrin-5 (Netrin-1-like protein)
Gene: NTN5

Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 489 Hs			1 2321
+	Hs
		804299 NET5_HUMAN (1-489): 1.06e-87: 278: 100.00		NOTC1_HUMAN (151-1604): 0: 663: 31.63
+	Hs
		980475 NET5_HUMAN (1-489): 1.06e-87: 278: 100.00		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Dm
		422762 NETB_DROME (143-472): 9.84e-53: 192: 31.10		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Hs
		317789 NET1_HUMAN (58-476): 4.08e-73: 244: 38.62		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Dm
		422715 LAMC1_DROME (20-327): 1.21e-27: 119: 15.82		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Dm
		90684 E1JHA6_DROME (120-460): 4.09e-13: 74.5: 10.63		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Dm
		422742 LAMA_DROME (4-222): 2.52e-11: 68.7: 11.71		NOTCH_DROME (496-1588): 8.18e-136: 479: 28.34
+	Hs
		877404 LAMB2_HUMAN (89-313): 5.5e-20: 96: 17.80		NOTC2_HUMAN (584-1691): 1.87e-117: 419: 26.15
+	Hs
		1259462 NET5_HUMAN (1-489): 1.06e-87: 278: 100.00		JAG2_HUMAN (2-416): 1.8e-37: 157: 26.53
+	Hs
		724385 NET5_HUMAN (1-489): 1.06e-87: 278: 100.00		FBN2_HUMAN (551-1692): 2.67e-31: 137: 14.76
+	Hs
		724350 NET5_HUMAN (1-489): 1.06e-87: 278: 100.00		FBN1_HUMAN (894-1610): 8.7e-17: 90: 15.75
+	Dm
		484988 NETB_DROME (143-472): 9.84e-53: 192: 31.10		CRB_DROME (1246-1525): 1.38e-16: 89.2: 18.79