HitPredict

Interactor 1: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	10858458, 15456872, 19531213, 15557335, 21191027, 17428861, 17174262, 18641129
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006915 - apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Hs			1 665
+	Hs
		1260427 PDC6I_HUMAN (1-868): 0: 677: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		924726 PDC6I_HUMAN (1-868): 0: 677: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1260413 PDC6I_HUMAN (1-868): 0: 677: 100.00		ITSN2_HUMAN (30-455): 2.08e-26: 117: 15.30
+	Hs
		1078881 PDC6I_HUMAN (1-868): 0: 677: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		1141174 PDC6I_MOUSE (1-868): 0: 638: 94.25		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		1191850 PDC6I_HUMAN (1-868): 0: 677: 100.00		SH3R1_HUMAN (241-599): 5.37e-12: 71.2: 13.28
+	Ce
		666203 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		SEM5_CAEEL (2-167): 1.56e-29: 118: 21.08
+	Ce
		712282 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48
+	Hs
		924858 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		1078907 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		275227 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		1167826 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82
+	Mm
		292687 PTN23_MOUSE (3-863): 1.62e-124: 414: 22.43		GRAP2_MOUSE (1-55): 2.15e-16: 82.8: 30.91
+	Hs
		1126375 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31
+	Hs
		724756 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		728465 MYH11_HUMAN (195-713): 8.34e-48: 187: 13.76		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		725134 MYH10_HUMAN (197-713): 1.83e-42: 170: 13.08		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		298957 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		924521 EP300_HUMAN (527-867): 6.39e-32: 136: 13.70		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		209071 TGO1_HUMAN (241-868): 3.47e-45: 178: 11.69		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77