HitPredict

Interactor 1: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.658

Property	Details
Experiments	15456872, 17174262, 17350572
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Hs			1 352
+	Hs
		1260385 PDC6I_HUMAN (1-868): 0: 677: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Mm
		1143926 PDC6I_MOUSE (1-868): 0: 638: 94.25		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Mm
		1143918 PDC6I_MOUSE (1-868): 0: 638: 94.25		SH3G1_MOUSE (1-352): 4.74e-84: 261: 69.02
+	Hs
		1191850 PDC6I_HUMAN (1-868): 0: 677: 100.00		SH3R1_HUMAN (287-346): 1.48e-12: 70.9: 42.19
+	Hs
		924726 PDC6I_HUMAN (1-868): 0: 677: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Ce
		70028 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		SH3GH_CAEEL (1-350): 5e-70: 225: 43.19
+	Hs
		1307434 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Mm
		1141174 PDC6I_MOUSE (1-868): 0: 638: 94.25		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Ce
		666203 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		SEM5_CAEEL (274-344): 2.29e-22: 95.6: 45.07
+	Hs
		924858 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		1126375 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Dm
		993211 Q9VUH6_DROME (4-865): 5.54e-107: 365: 21.32		GRAP_DROME (274-344): 7.28e-20: 88.3: 38.03
+	Hs
		724825 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		969584 CENPE_HUMAN (218-699): 3.42e-67: 247: 14.20		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		724817 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		522612 MYH7_HUMAN (158-714): 1.65e-47: 186: 13.06		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		724756 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		298957 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		SRBS2_HUMAN (296-347): 7.69e-10: 62.4: 51.92
+	Hs
		728465 MYH11_HUMAN (195-713): 8.34e-48: 187: 13.76		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		725134 MYH10_HUMAN (197-713): 1.83e-42: 170: 13.08		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10