HitPredict

Interactor 1: PDC6I (Q8WUM4)
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)
Gene: PDCD6IP

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.647

Property	Details
Experiments	17428861, 17853893, unassigned1973
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006915 - apoptotic process GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 868 Hs			1 639
+	Hs
		1260375 PDC6I_HUMAN (1-868): 0: 677: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		924726 PDC6I_HUMAN (1-868): 0: 677: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141174 PDC6I_MOUSE (1-868): 0: 638: 94.25		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		1260413 PDC6I_HUMAN (1-868): 0: 677: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		1078881 PDC6I_HUMAN (1-868): 0: 677: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		275227 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Ce
		712280 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		Q95PW9_CAEEL (109-333): 8.42e-19: 90.8: 21.68
+	Mm
		292687 PTN23_MOUSE (3-863): 1.62e-124: 414: 22.43		GRAP2_MOUSE (2-328): 2.38e-46: 168: 15.27
+	Hs
		924858 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Ce
		712282 ALXA_CAEEL (4-831): 3.18e-164: 502: 37.92		Q9U2T9_CAEEL (27-492): 3.56e-11: 68.5: 13.89
+	Hs
		1167826 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		1078907 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		1126375 PTN23_HUMAN (3-868): 1.49e-131: 432: 23.93		SH319_HUMAN (75-368): 3.05e-10: 65.4: 17.45
+	Hs
		209071 TGO1_HUMAN (241-868): 3.47e-45: 178: 11.69		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		724756 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		728465 MYH11_HUMAN (195-713): 8.34e-48: 187: 13.76		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		725134 MYH10_HUMAN (197-713): 1.83e-42: 170: 13.08		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		298957 MYH9_HUMAN (163-716): 5.84e-59: 221: 15.01		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Hs
		924521 EP300_HUMAN (527-867): 6.39e-32: 136: 13.70		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		60537 VP37C_HUMAN (540-856): 2.14e-25: 110: 18.81		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28