HitPredict

Interactor 1: BMAL1 (O00327)
Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
Gene: BMAL1

Interactor 2: CLOCK (O15516)
Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)
Gene: CLOCK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 23555304, 28514442, 27173435, 30287810, 32296183, 11439184, 19922678, 26164627, 14701734, 33961781, 20551151, 11018023, 28388406, 31515488, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, pull down, protein complementation assay, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach, validated two hybrid, mammalian protein protein interaction trap
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0005634 - nucleus
and 22 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 626
Hs

1 846
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Last updated: 15 Jul 2024