HitPredict

Interactor 1: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	11071869, 22262777, 21822214
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 665
+	Mm
		1246941 BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		1261033 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		655439 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		557750 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924727 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		222321 O54737_MOUSE (1-444): 3.19e-60: 206: 58.22		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		275217 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Mm
		292689 BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56		GRAP2_MOUSE (1-55): 2.15e-16: 82.8: 30.91
+	Hs
		209129 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		548737 BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		129269 P85B_HUMAN (129-453): 1.23e-44: 168: 17.05		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		557615 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		655306 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Mm
		643091 P85A_MOUSE (121-453): 4.26e-43: 163: 14.41		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		924670 CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		655386 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Hs
		548645 P85A_HUMAN (121-453): 1.18e-43: 164: 15.54		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Ce
		110116 TENSH_CAEEL (7-436): 5.69e-38: 149: 13.32		Q9U2T9_CAEEL (142-349): 4.59e-14: 78.1: 18.48
+	Hs
		275193 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		209043 LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77