HitPredict

Interactor 1: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Interactor 2: UBE2W (Q96B02)
Ubiquitin-conjugating enzyme E2 W (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme W) (N-terminal E2 ubiquitin-conjugating enzyme) (EC 2.3.2.25) (N-terminus-conjugating E2) (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Gene: UBE2W

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 151
+	Hs
		1261313 RN138_HUMAN (1-245): 6.92e-57: 183: 100.00		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		919801 RN138_HUMAN (1-245): 6.92e-57: 183: 100.00		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		1283434 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Hs
		849395 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919812 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895868 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1283415 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1282321 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		1377468 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2D4_HUMAN (4-150): 7.3e-70: 208: 35.37
+	Ce
		283756 O76354_CAEEL (13-239): 2.07e-34: 131: 15.90		UBC2_CAEEL (4-150): 6.67e-69: 206: 34.01
+	Hs
		849499 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		851861 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		849496 TRAF6_HUMAN (12-245): 1.55e-33: 128: 16.25		UB2D1_HUMAN (4-150): 2.02e-69: 207: 34.69
+	Hs
		919918 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2D2_HUMAN (4-150): 1.14e-68: 205: 33.33
+	Hs
		895969 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2D3_HUMAN (4-150): 3.12e-67: 202: 33.33
+	Hs
		1283412 RN166_HUMAN (5-244): 4.23e-40: 140: 29.58		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00
+	Hs
		1297384 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2E2_HUMAN (1-150): 3.17e-66: 201: 34.67
+	Hs
		1282369 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2E3_HUMAN (1-150): 1.13e-65: 200: 35.33
+	Hs
		851914 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UB2E1_HUMAN (1-150): 3.64e-64: 196: 34.00
+	Hs
		1284902 RN114_HUMAN (16-241): 4.34e-36: 129: 30.53		UBE2W_HUMAN (1-151): 1.05e-62: 190: 100.00