HitPredict

Interactor 1: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16714285
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0019901 - protein kinase binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 619
+	Hs
		1261310 RN138_HUMAN (1-245): 6.92e-57: 183: 100.00		LEF1_HUMAN (11-448): 4e-41: 155: 48.19
+	Hs
		585039 RO52_HUMAN (6-157): 6.92e-32: 123: 17.11		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		1223389 TRI22_HUMAN (11-171): 1.31e-29: 117: 14.97		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		1300908 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		817987 TRI26_HUMAN (4-239): 2.73e-33: 127: 15.64		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		988011 RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		727853 RING1_HUMAN (2-74): 3.94e-21: 92.7: 27.40		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		996853 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		SSRP1_HUMAN (333-511): 2.38e-26: 116: 18.89
+	Hs
		1313366 TRAF4_HUMAN (8-207): 1.85e-27: 111: 13.14		HM20A_HUMAN (250-461): 2.79e-27: 115: 14.15
+	Hs
		818385 RING2_HUMAN (2-188): 8.11e-29: 112: 18.72		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Mm
		1321738 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		HM20A_MOUSE (248-461): 5.04e-26: 111: 13.43
+	Mm
		818761 RING2_MOUSE (2-188): 1.78e-28: 112: 18.72		SOX2_MOUSE (318-613): 2.17e-26: 111: 14.15
+	Hs
		818546 KCMF1_HUMAN (147-236): 1.38e-25: 105: 32.22		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69