HitPredict

Interactor 1: TWST2 (Q8WVJ9)
Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)
Gene: TWIST2

Interactor 2: HTF4 (Q99081)
Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
Gene: TCF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.933

Property	Details
Experiments	25416956, 32296183, 21516116, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II and 1 others more... GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 160 Hs			1 682
+	Hs
		1076858 TWST1_HUMAN (1-160): 1.29e-34: 121: 59.20		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Hs
		616615 MYF6_HUMAN (1-137): 2.72e-29: 109: 22.86		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Mm
		644476 TWST1_MOUSE (1-160): 2.99e-34: 120: 56.59		HTF4_MOUSE (1-682): 0: 907: 92.21
+	Hs
		1018388 TCF15_HUMAN (18-139): 9.34e-27: 101: 36.00		HTF4_HUMAN (1-682): 0: 921: 100.00
+	Mm
		644472 TWST1_MOUSE (1-160): 2.99e-34: 120: 56.59		ITF2_MOUSE (2-682): 0: 804: 62.82
+	Hs
		551220 TWST2_HUMAN (1-160): 2.57e-43: 142: 100.00		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551151 TWST1_HUMAN (1-160): 1.29e-34: 121: 59.20		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551559 TWST2_HUMAN (1-160): 2.57e-43: 142: 100.00		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		551069 MYF6_HUMAN (1-137): 2.72e-29: 109: 22.86		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551135 TCF15_HUMAN (18-139): 9.34e-27: 101: 36.00		ITF2_HUMAN (2-682): 0: 777: 62.01
+	Hs
		551530 TWST1_HUMAN (1-160): 1.29e-34: 121: 59.20		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Rn
		600265 Q9EPJ1_RAT (1-160): 9.78e-35: 121: 57.43		TFE2_RAT (1-682): 0: 752: 49.14
+	Hs
		551472 MYF6_HUMAN (1-137): 2.72e-29: 109: 22.86		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		551515 TCF15_HUMAN (18-139): 9.34e-27: 101: 36.00		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Hs
		526739 MYF5_HUMAN (3-142): 6.56e-26: 100: 24.34		TFE2_HUMAN (2-682): 0: 753: 48.93
+	Mm
		550182 TWST1_MOUSE (1-160): 2.99e-34: 120: 56.59		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		550186 ATOH1_MOUSE (48-138): 2.77e-25: 100: 35.42		TFE2_MOUSE (1-682): 0: 732: 49.43
+	Mm
		823150 ATOH1_MOUSE (48-138): 2.77e-25: 100: 35.42		Q91YV0_MOUSE (193-682): 0: 598: 64.41
+	Dm
		496114 TWIST_DROME (4-152): 3.02e-25: 102: 35.87		DA_DROME (272-679): 1.33e-107: 343: 36.92
+	Dm
		509377 FER3_DROME (42-140): 2.76e-26: 100: 30.00		DA_DROME (272-679): 1.33e-107: 343: 36.92