HitPredict

Interactor 1: SCFD1 (Q8WVM8)
Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)
Gene: SCFD1

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~Sec1
Common GO terms	GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0019905 - syntaxin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 642 Hs			1 236
+	Hs
		235200 SCFD1_HUMAN (14-642): 0: 644: 100.00		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	Hs
		212953 SCFD1_HUMAN (14-642): 0: 644: 100.00		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Hs
		320371 SCFD1_HUMAN (14-642): 0: 644: 100.00		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169556 SCFD1_HUMAN (14-642): 0: 644: 100.00		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Dm
		1096658 SLY1_DROME (13-642): 0: 572: 56.81		Q9VV76_DROME (4-223): 7.2e-43: 146: 24.32
+	Dm
		1096659 SLY1_DROME (13-642): 0: 572: 56.81		Q9VVX6_DROME (161-234): 4.68e-13: 65.7: 20.00
+	At
		1319854 KEULE_ARATH (16-639): 9.61e-169: 498: 17.33		SNP30_ARATH (11-210): 1.2e-39: 139: 14.71
+	At
		1319855 KEULE_ARATH (16-639): 9.61e-169: 498: 17.33		SNP33_ARATH (11-210): 1.79e-38: 137: 15.69
+	Hs
		235214 VPS45_HUMAN (38-640): 9.73e-154: 456: 20.66		STX10_HUMAN (3-221): 2.24e-51: 168: 17.39
+	At
		1319856 KEULE_ARATH (16-639): 9.61e-169: 498: 17.33		SNP29_ARATH (11-210): 1.21e-33: 123: 11.77
+	Hs
		1345175 VPS45_HUMAN (38-640): 9.73e-154: 456: 20.66		STX8_HUMAN (1-218): 7.54e-47: 156: 100.00
+	Hs
		213020 VPS45_HUMAN (38-640): 9.73e-154: 456: 20.66		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30
+	Sc
		605780 SLY1_YEAST (1-640): 7.62e-163: 483: 31.55		BET1_YEAST (93-235): 4.89e-27: 102: 18.06
+	Hs
		320426 VPS45_HUMAN (38-640): 9.73e-154: 456: 20.66		SNP29_HUMAN (10-207): 2.95e-28: 109: 20.50
+	Hs
		169625 VPS45_HUMAN (38-640): 9.73e-154: 456: 20.66		BET1_HUMAN (149-234): 6.31e-25: 96.8: 18.61
+	Sc
		758048 VPS45_YEAST (33-638): 1.86e-126: 387: 18.03		TLG1_YEAST (2-220): 3.95e-32: 118: 15.07
+	Hs
		212997 VP33B_HUMAN (3-639): 2.08e-111: 349: 13.40		STX6_HUMAN (3-221): 2.26e-43: 148: 17.30