HitPredict

Interactor 1: DC2I1 (Q8WVS4)
Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)
Gene: DYNC2I1

Interactor 2: DYL2 (Q96FJ2)
Dynein light chain 2, cytoplasmic (8 kDa dynein light chain b) (DLC8b) (Dynein light chain LC8-type 2)
Gene: DYNLL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27173435, 33961781, 35271311
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005868 - cytoplasmic dynein complex GO:0005929 - cilium GO:0097542 - ciliary tip
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1066 Hs			1 89
+	Hs
		928412 DC2I1_HUMAN (1-1066): 0: 812: 100.00		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		148059 DC1I1_HUMAN (376-1056): 5.44e-177: 533: 16.90		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Mm
		291681 DC1I1_MOUSE (376-1056): 3.36e-177: 533: 17.60		DYL1_MOUSE (1-89): 1.8e-47: 147: 93.26
+	Hs
		148093 DC1I1_HUMAN (376-1056): 5.44e-177: 533: 16.90		DYL2_HUMAN (1-89): 7.09e-47: 146: 100.00
+	Hs
		928281 DC1I2_HUMAN (382-1056): 3.33e-166: 505: 16.71		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26
+	Hs
		1033319 DC1I2_HUMAN (382-1056): 3.33e-166: 505: 16.71		DYL2_HUMAN (1-89): 7.09e-47: 146: 100.00
+	Dm
		1096026 DYIN_DROME (566-1056): 3.64e-112: 364: 19.68		DYL1_DROME (1-89): 7.55e-48: 148: 96.63
+	Ce
		219878 O45087_CAEEL (338-1056): 3.02e-64: 231: 15.72		DYL1_CAEEL (1-89): 5.57e-47: 146: 95.51
+	Hs
		551662 DESP_HUMAN (1-554): 5.69e-14: 79.3: 12.35		DYL1_HUMAN (1-89): 1.8e-47: 147: 93.26