HitPredict

Interactor 1: Q8WWE8 (Q8WWE8)
CYTH4 protein
Gene: CYTH4

Interactor 2: CNKR1 (Q969H4)
Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR 1) (CNK homolog protein 1) (CNK1) (hCNK1) (Connector enhancer of KSR-like)
Gene: CNKSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Sec7
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 720
+	Hs
		1281534 CYH4_HUMAN (1-118): 1.51e-45: 153: 100.00		CNKR1_HUMAN (1-720): 0: 556: 100.00
+	Hs
		1281529 CYH2_HUMAN (7-118): 9.02e-42: 143: 49.11		CNKR1_HUMAN (1-720): 0: 556: 100.00
+	Hs
		1074109 CYH1_HUMAN (8-118): 6.3e-41: 140: 56.76		CNKR1_HUMAN (1-720): 0: 556: 100.00
+	Hs
		212319 CYH3_HUMAN (22-118): 7.38e-36: 127: 57.73		CNKR1_HUMAN (1-720): 0: 556: 100.00
+	Mm
		926282 CYH2_MOUSE (7-118): 4.88e-42: 144: 50.00		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Mm
		1194493 CYH1_MOUSE (8-118): 9.26e-42: 143: 55.86		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Mm
		140106 CYH3_MOUSE (22-118): 7.65e-36: 127: 57.73		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Hs
		212313 CYH1_HUMAN (8-118): 6.3e-41: 140: 56.76		CYH3_HUMAN (165-502): 6.16e-58: 203: 13.50
+	Hs
		1074113 CYH2_HUMAN (7-118): 9.02e-42: 143: 49.11		CYH1_HUMAN (165-524): 2.61e-50: 182: 13.51
+	Mm
		1194484 IQEC1_MOUSE (51-118): 2.95e-24: 97.8: 35.29		CNKR2_MOUSE (77-719): 4.09e-59: 218: 18.20
+	Dm
		1360475 Q9V9Q6_DROME (9-118): 2.17e-39: 137: 48.18		Q9V9Q6_DROME (125-521): 4.48e-43: 162: 12.35
+	Dm
		1181488 Q9V9Q6_DROME (9-118): 2.17e-39: 137: 48.18		Q7KNQ9_DROME (243-601): 6.95e-22: 103: 16.45
+	Hs
		1262772 CYH4_HUMAN (1-118): 1.51e-45: 153: 100.00		ICEF1_HUMAN (504-704): 8.62e-15: 79.4: 26.37
+	Hs
		1331765 BIG1_HUMAN (7-117): 1.01e-30: 116: 27.43		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		1331764 BIG2_HUMAN (11-117): 6.89e-30: 114: 23.08		PKHA4_HUMAN (383-502): 7.85e-26: 115: 26.40
+	Hs
		1262771 CYH2_HUMAN (7-118): 9.02e-42: 143: 49.11		ICEF1_HUMAN (504-704): 8.62e-15: 79.4: 26.37
+	Hs
		1074107 CYH1_HUMAN (8-118): 6.3e-41: 140: 56.76		ICEF1_HUMAN (504-704): 8.62e-15: 79.4: 26.37
+	Hs
		212317 CYH3_HUMAN (22-118): 7.38e-36: 127: 57.73		ICEF1_HUMAN (504-704): 8.62e-15: 79.4: 26.37