HitPredict

Interactor 1: ODPX (O00330)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)
Gene: PDHX

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26186194, 28514442, 29568061
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 436
+	Hs
		126246 ODPX_HUMAN (1-501): 0: 586: 100.00		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		126247 ODPX_HUMAN (1-501): 0: 586: 100.00		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Hs
		81542 ODPX_HUMAN (1-501): 0: 586: 100.00		B7Z207_HUMAN (156-436): 1.39e-167: 473: 100.00
+	Hs
		739124 ODO2_HUMAN (19-500): 2.29e-128: 382: 22.93		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Mm
		222971 ODB2_MOUSE (6-500): 6.02e-161: 466: 25.79		BCKD_MOUSE (1-398): 3.29e-160: 459: 28.27
+	Hs
		489747 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		489748 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		489749 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Mm
		222980 ODP2_MOUSE (12-145): 1.85e-31: 130: 36.57		BCKD_MOUSE (1-398): 3.29e-160: 459: 28.27