HitPredict

Interactor 1: ODPX (O00330)
Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)
Gene: PDHX

Interactor 2: PDK3 (Q15120)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
Gene: PDK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 406
+	Hs
		126245 ODPX_HUMAN (1-501): 0: 586: 100.00		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Hs
		126246 ODPX_HUMAN (1-501): 0: 586: 100.00		PDK2_HUMAN (1-405): 0: 602: 66.50
+	Hs
		81542 ODPX_HUMAN (1-501): 0: 586: 100.00		B7Z207_HUMAN (126-404): 2.44e-158: 448: 69.40
+	Hs
		739124 ODO2_HUMAN (19-500): 2.29e-128: 382: 22.93		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Mm
		222971 ODB2_MOUSE (6-500): 6.02e-161: 466: 25.79		BCKD_MOUSE (16-363): 3.35e-137: 400: 28.02
+	Hs
		489749 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK3_HUMAN (1-406): 0: 642: 100.00
+	Hs
		489747 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK1_HUMAN (10-404): 0: 619: 68.26
+	Hs
		489748 ODP2_HUMAN (11-277): 8.66e-33: 134: 21.50		PDK2_HUMAN (1-405): 0: 602: 66.50
+	Mm
		222980 ODP2_MOUSE (12-145): 1.85e-31: 130: 36.57		BCKD_MOUSE (16-363): 3.35e-137: 400: 28.02