HitPredict

Interactor 1: ATX2L (Q8WWM7)
Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)
Gene: ATXN2L

Interactor 2: ATX2 (Q99700)
Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein)
Gene: ATXN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	24981860, 23209657
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SM-ATX~SM-ATX
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:0016020 - membrane and 1 others more... GO:0034063 - stress granule assembly
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1075 Hs			1 1313
+	Hs
		1056953 MDC1_HUMAN (4-779): 4.69e-18: 92.3: 9.29		ATX2_HUMAN (1-1313): 1.72e-116: 397: 100.00
+	Sc
		861269 PBP1_YEAST (86-726): 2.04e-27: 121: 16.04		PBP1_YEAST (299-661): 2.63e-35: 146: 21.11
+	Hs
		554259 MUC1_HUMAN (643-1046): 1.14e-16: 87.7: 10.40		MUC1_HUMAN (699-1312): 1.2e-29: 130: 10.26
+	Hs
		1303336 MUC4_HUMAN (250-1058): 9.62e-11: 68.8: 8.69		MUC4_HUMAN (120-1313): 2.63e-29: 130: 9.35
+	Mm
		1351630 PCLO_MOUSE (5-1000): 4.6e-21: 102: 9.82		PCLO_MOUSE (966-1313): 9.21e-09: 62.5: 9.77
+	Hs
		1300971 CHD7_HUMAN (306-840): 4.88e-17: 89.3: 10.22		CIC_HUMAN (3-783): 2.62e-10: 67.5: 10.47
+	Dm
		113976 M9PB30_DROME (6-698): 8.12e-11: 68.8: 8.51		M9PB30_DROME (8-712): 1.36e-11: 71.7: 9.12
+	Hs
		867119 SC24C_HUMAN (613-1018): 1.53e-10: 67.5: 11.79		CIC_HUMAN (3-783): 2.62e-10: 67.5: 10.47
+	Dm
		1214590 Q8IQA6_DROME (310-1057): 8.6e-10: 65.4: 9.84		Q9VLS7_DROME (1-695): 1.23e-10: 68.6: 8.91