HitPredict

Interactor 1: ATX2L (Q8WWM7)
Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein)
Gene: ATXN2L

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	24981860, 26186194, 28514442, 33961781, 35271311, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:0034063 - stress granule assembly
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1075 Hs			1 482
+	Hs
		1030384 ATX2L_HUMAN (1-1075): 6.36e-139: 447: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1305721 ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1030437 ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		867095 SC24C_HUMAN (613-1018): 1.53e-10: 67.5: 11.79		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Sc
		861272 PBP1_YEAST (86-726): 2.04e-27: 121: 16.04		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		1236629 ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82		CELF5_HUMAN (293-418): 4.09e-17: 85.7: 17.83
+	Hs
		1272084 ATX2_HUMAN (176-847): 3.45e-11: 70: 10.82		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63