HitPredict

Interactor 1: PRP31 (Q8WWY3)
U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)
Gene: PRPF31

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26275778
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0071339 - MLL1 complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 499 Hs			1 456
+	Hs
		1377041 NOP58_HUMAN (24-354): 4.73e-126: 379: 22.97		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Mm
		888072 NOP58_MOUSE (24-354): 2.1e-125: 377: 22.97		RUVB1_MOUSE (1-456): 0: 704: 99.78
+	Sc
		830824 PRP31_YEAST (5-426): 9e-129: 385: 26.68		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Hs
		1376980 NOP58_HUMAN (24-354): 4.73e-126: 379: 22.97		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sc
		830836 PRP31_YEAST (5-426): 9e-129: 385: 26.68		RUVB2_YEAST (5-455): 0: 627: 41.72
+	Sc
		978061 NOP58_YEAST (3-352): 6.6e-112: 342: 20.73		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		1015639 NOP58_YEAST (3-352): 6.6e-112: 342: 20.73		RUVB2_YEAST (5-455): 0: 627: 41.72