Interactor 1: PYDC1 (Q8WXC3)
Pyrin domain-containing protein 1 (PAAD-only protein 1) (Pyrin-only protein 1) (cellular POP1) (cPOP1)
Gene: PYDC1

Interactor 2: ASC (Q9ULZ3)
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
Gene: PYCARD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.879

The method score is based on:

Property Details
Experiments 17178784, 12656673, 19337385, 18362139
Identification Methods anti tag coimmunoprecipitation, pull down, two hybrid, surface plasmon resonance
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PYRIN~PYRIN
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0008385 - IkappaB kinase complex
GO:0032088 - negative regulation of NF-kappaB transcription factor activity
GO:0032731 - positive regulation of interleukin-1 beta production
and 2 others

more...

Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 89
Hs

1 195
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Last updated: 15 Jul 2024