HitPredict

Interactor 1: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.895

Property	Details
Experiments	28514442, 31253590, 33961781, 21145461
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 780
+	Mm
		1265273 SOCS4_MOUSE (1-439): 5.13e-170: 485: 86.79		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		256856 SOCS5_HUMAN (7-436): 2.94e-135: 401: 52.72		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		222648 SOCS5_MOUSE (7-436): 1.54e-131: 391: 52.26		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		1274062 CISH_HUMAN (212-425): 3.46e-50: 172: 22.93		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1322060 SOCS6_MOUSE (204-424): 1.31e-47: 173: 29.46		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146642 SOCS2_HUMAN (234-425): 9.62e-47: 161: 25.85		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		181885 SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		146692 SOCS7_HUMAN (209-439): 3.54e-40: 153: 22.76		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193357 SOCS1_MOUSE (260-425): 1.6e-45: 158: 22.29		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193366 SOCS2_MOUSE (234-425): 2.17e-45: 158: 26.34		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147544 SOCS6_HUMAN (239-424): 7.84e-40: 151: 32.00		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1257617 SOCS7_MOUSE (209-439): 1.39e-40: 154: 22.76		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1143676 CISH_MOUSE (211-425): 1.16e-40: 147: 23.32		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147440 SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		193394 SOCS3_MOUSE (250-422): 1.02e-38: 141: 20.09		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		411713 LCK_HUMAN (195-418): 6.26e-42: 156: 15.88		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		146625 SOCS2_HUMAN (234-425): 9.62e-47: 161: 25.85		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		147421 SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041477 CISH_HUMAN (212-425): 3.46e-50: 172: 22.93		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Hs
		181856 SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29		CUL2_HUMAN (6-780): 0: 699: 26.36