HitPredict

Interactor 1: AUTS2 (Q8WXX7)
Autism susceptibility gene 2 protein
Gene: AUTS2

Interactor 2: PCGF6 (Q9BYE7)
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)
Gene: PCGF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	25519132, 28514442, 27705803, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1259 Hs			1 350
+	Hs
		1108524 AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Mm
		393 AUTS2_MOUSE (1-1259): 7.09e-133: 440: 90.25		PCGF3_MOUSE (120-341): 1.16e-63: 204: 34.58
+	Hs
		1197576 AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		1264228 AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		987999 AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Mm
		397 AUTS2_MOUSE (1-1259): 7.09e-133: 440: 90.25		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		1316706 FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03		PCGF6_HUMAN (1-350): 1.95e-96: 291: 100.00
+	Mm
		1161097 Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01		PCGF3_MOUSE (120-341): 1.16e-63: 204: 34.58
+	Hs
		554277 MUC1_HUMAN (21-960): 4.41e-54: 209: 12.26		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Mm
		1112807 Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01		PCGF5_MOUSE (117-344): 9.38e-51: 171: 32.13
+	Hs
		1108546 FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03		PCGF3_HUMAN (120-341): 3.31e-65: 208: 34.44
+	Mm
		1161099 Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01		RING2_MOUSE (85-303): 2.38e-32: 125: 14.49
+	Hs
		718208 FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54		BMI1_HUMAN (117-349): 8.67e-71: 225: 34.30
+	Hs
		718429 FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54		PCGF2_HUMAN (117-350): 6.32e-65: 211: 33.47
+	Mm
		193409 Q6PED7_MOUSE (637-1259): 1.68e-63: 230: 92.01		RING1_MOUSE (109-211): 8.51e-26: 108: 25.96
+	Hs
		1197593 FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03		PCGF5_HUMAN (117-344): 6.93e-50: 169: 31.73
+	Hs
		1304118 FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		988026 FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96
+	Hs
		111280 J3KNZ9_HUMAN (480-885): 7.73e-30: 130: 39.22		RING2_HUMAN (85-303): 3.51e-32: 124: 14.49
+	Hs
		988023 FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54		RING1_HUMAN (109-211): 1.44e-25: 108: 25.96