HitPredict

Interactor 1: MYLIP (Q8WY64)
E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)
Gene: MYLIP

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 1164
+	Hs
		547162 EZRI_HUMAN (1-376): 3e-91: 289: 21.12		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		640134 MOES_HUMAN (1-382): 6.97e-88: 280: 20.25		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Mm
		640194 EZRI_MOUSE (1-396): 5.69e-91: 289: 21.66		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Mm
		640210 RADI_MOUSE (1-385): 1.03e-89: 285: 21.25		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Mm
		640201 MOES_MOUSE (1-382): 1.98e-87: 279: 21.00		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		1203617 MYLIP_HUMAN (1-445): 3.33e-129: 382: 100.00		Q86WV8_HUMAN (1-343): 3.4e-177: 526: 100.00
+	Hs
		505632 EPB41_HUMAN (1-394): 2.24e-103: 328: 21.05		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		505568 EPB41_HUMAN (1-394): 2.24e-103: 328: 21.05		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		1331065 E41L1_HUMAN (2-387): 2.23e-105: 334: 21.48		MYH4_HUMAN (393-969): 2.58e-19: 96.8: 11.22
+	Hs
		505542 EPB41_HUMAN (1-394): 2.24e-103: 328: 21.05		MYH1_HUMAN (393-967): 5.76e-21: 102: 11.23
+	Hs
		148997 FRMD5_HUMAN (3-400): 3.16e-92: 291: 21.64		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		148355 EZRI_HUMAN (1-376): 3e-91: 289: 21.12		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		505569 EPB41_HUMAN (1-394): 2.24e-103: 328: 21.05		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		640054 MOES_HUMAN (1-382): 6.97e-88: 280: 20.25		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Dm
		1360334 EPB41_DROME (4-371): 3.77e-95: 315: 22.75		Q9VCC9_DROME (835-1160): 2.53e-09: 63.7: 9.76
+	Hs
		547095 EZRI_HUMAN (1-376): 3e-91: 289: 21.12		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		1035182 FRMD5_HUMAN (3-400): 3.16e-92: 291: 21.64		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Hs
		1137909 E41LA_HUMAN (2-385): 2.37e-88: 284: 18.89		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		547271 EZRI_HUMAN (1-376): 3e-91: 289: 21.12		MYH13_HUMAN (628-994): 2.22e-10: 67.5: 20.45
+	Hs
		640092 MOES_HUMAN (1-382): 6.97e-88: 280: 20.25		CENPE_HUMAN (620-984): 9.03e-10: 65.5: 20.36