HitPredict

Interactor 1: MYLIP (Q8WY64)
E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP)
Gene: MYLIP

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 280
+	Hs
		434097 FARP1_HUMAN (4-375): 1.47e-116: 367: 25.13		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		411904 FARP1_HUMAN (4-375): 1.47e-116: 367: 25.13		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		412416 E41L3_HUMAN (1-420): 5e-108: 345: 21.65		FYN_HUMAN (4-280): 4.46e-57: 193: 18.77
+	Hs
		523221 E41L3_HUMAN (1-420): 5e-108: 345: 21.65		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Hs
		434091 E41L3_HUMAN (1-420): 5e-108: 345: 21.65		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		337601 E41L3_HUMAN (1-420): 5e-108: 345: 21.65		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		411899 E41L3_HUMAN (1-420): 5e-108: 345: 21.65		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		434008 E41L1_HUMAN (2-387): 2.23e-105: 334: 21.48		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		411855 E41L1_HUMAN (2-387): 2.23e-105: 334: 21.48		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		433541 EPB41_HUMAN (1-394): 2.24e-103: 328: 21.05		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		299230 FARP2_HUMAN (1-382): 8.12e-100: 322: 22.25		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		434020 E41L5_HUMAN (1-375): 2.15e-102: 322: 24.08		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		204599 E41L2_HUMAN (1-346): 1.08e-99: 321: 24.22		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		434004 E41LB_HUMAN (1-385): 2.36e-100: 321: 25.26		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Hs
		412035 PTN4_HUMAN (1-383): 5.5e-97: 312: 24.94		FYN_HUMAN (4-280): 4.46e-57: 193: 18.77
+	Hs
		411867 E41L5_HUMAN (1-375): 2.15e-102: 322: 24.08		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		337358 PTN4_HUMAN (1-383): 5.5e-97: 312: 24.94		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		523042 FRMD5_HUMAN (3-400): 3.16e-92: 291: 21.64		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Hs
		557617 PTN4_HUMAN (1-383): 5.5e-97: 312: 24.94		NCK1_HUMAN (34-127): 1.07e-39: 143: 34.04
+	Mm
		250716 E41L2_MOUSE (1-398): 1.96e-99: 320: 21.43		PLCG2_MOUSE (4-198): 3.76e-22: 97.9: 20.83