HitPredict

Interactor 1: ATG4A (Q8WYN0)
Cysteine protease ATG4A (EC 3.4.22.-) (AUT-like 2 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 2) (Autophagin-2) (Autophagy-related protein 4 homolog A) (HsAPG4A) (hAPG4A)
Gene: ATG4A

Interactor 2: MLP3B (Q9GZQ8)
Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)
Gene: MAP1LC3B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.844

Property	Details
Experiments	28287329, 31006538, 20010802
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0000423 - mitophagy GO:0006914 - autophagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 398 Hs			1 125
+	Hs
		1264550 ATG4A_HUMAN (1-398): 0: 603: 100.00		MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50
+	Hs
		891248 ATG4A_HUMAN (1-398): 0: 603: 100.00		GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47
+	Hs
		306253 ATG4A_HUMAN (1-398): 0: 603: 100.00		GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30
+	Hs
		1264549 ATG4A_HUMAN (1-398): 0: 603: 100.00		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46
+	Hs
		1326231 ATG4B_HUMAN (19-398): 0: 546: 54.64		MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00
+	Hs
		61909 ATG4B_HUMAN (19-398): 0: 546: 54.64		MP3B2_HUMAN (1-125): 5e-56: 172: 99.20
+	Mm
		1206409 ATG4B_MOUSE (19-398): 0: 548: 56.07		MLP3A_MOUSE (1-120): 8.21e-55: 168: 82.50
+	Hs
		1330686 ATG4B_HUMAN (19-398): 0: 546: 54.64		MLP3A_HUMAN (1-120): 8.21e-55: 168: 82.50
+	Hs
		891370 ATG4B_HUMAN (19-398): 0: 546: 54.64		GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47
+	Hs
		306368 ATG4B_HUMAN (19-398): 0: 546: 54.64		GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30
+	Hs
		1315816 ATG4B_HUMAN (19-398): 0: 546: 54.64		MLP3C_HUMAN (1-120): 2.08e-51: 161: 55.00
+	Hs
		1328075 ATG4B_HUMAN (19-398): 0: 546: 54.64		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46
+	Ce
		111920 ATG41_CAEEL (15-398): 6.27e-163: 467: 38.90		LGG1_CAEEL (6-120): 5.55e-51: 159: 33.04
+	Ce
		111921 ATG41_CAEEL (15-398): 6.27e-163: 467: 38.90		LGG2_CAEEL (6-120): 6.06e-45: 144: 58.26
+	Hs
		1198602 ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10		MLP3B_HUMAN (1-125): 8.28e-57: 173: 100.00
+	Hs
		891203 ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10		GBRL2_HUMAN (7-120): 2.21e-53: 165: 39.47
+	Hs
		306219 ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10		GBRAP_HUMAN (7-121): 6.4e-53: 163: 31.30
+	Hs
		1198603 ATG4D_HUMAN (27-358): 1.13e-137: 403: 31.10		GBRL1_HUMAN (7-120): 1.5e-51: 160: 32.46
+	Dm
		1179054 Q9VPW2_DROME (20-392): 8.03e-135: 393: 40.58		Q7K1J3_DROME (1-120): 3.05e-50: 158: 29.17
+	Dm
		1364631 Q9VPW2_DROME (20-392): 8.03e-135: 393: 40.58		Q9VEG5_DROME (1-120): 1.37e-50: 158: 29.17