HitPredict

Interactor 1: MELPH (Q91V27)
Melanophilin (Exophilin-3) (Leaden protein) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a)
Gene: Mlph

Interactor 2: RB27A (Q9ERI2)
Ras-related protein Rab-27A (EC 3.6.5.2)
Gene: Rab27a

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.874

Property	Details
Experiments	12578829, 11887186, 18940604, 11773082
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0030318 - melanocyte differentiation GO:0031489 - myosin V binding GO:0042470 - melanosome GO:0043473 - pigmentation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Mm			1 221
+	Mm
		1265038 MELPH_MOUSE (1-590): 0: 554: 100.00		RB27B_MOUSE (1-221): 4.19e-77: 232: 71.49
+	Hs
		845948 MELPH_HUMAN (1-589): 0: 540: 63.68		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		119869 MELPH_HUMAN (1-589): 0: 540: 63.68		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Mm
		926085 MELPH_MOUSE (1-590): 0: 554: 100.00		RAB3A_MOUSE (2-192): 9.5e-57: 181: 43.98
+	Hs
		895544 MELPH_HUMAN (1-589): 0: 540: 63.68		RAB10_HUMAN (1-184): 1.04e-49: 162: 42.94
+	Hs
		845940 SYTL5_HUMAN (2-412): 1.96e-92: 301: 22.17		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Mm
		1193404 SYTL5_MOUSE (2-421): 2.92e-91: 298: 19.32		RB27A_MOUSE (1-221): 3.76e-82: 245: 100.00
+	Hs
		119864 SYTL5_HUMAN (2-412): 1.96e-92: 301: 22.17		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Mm
		722693 RIMS2_MOUSE (3-463): 2.15e-81: 281: 13.83		RAB3D_MOUSE (2-221): 1.04e-85: 254: 40.46
+	Hs
		914240 SYTL5_HUMAN (2-412): 1.96e-92: 301: 22.17		RB11A_HUMAN (3-220): 2.86e-77: 233: 34.84
+	Hs
		845927 SYTL3_HUMAN (1-268): 5.19e-74: 249: 22.30		RB27A_HUMAN (1-221): 3.76e-82: 245: 95.93
+	Hs
		119859 SYTL3_HUMAN (1-268): 5.19e-74: 249: 22.30		RB27B_HUMAN (1-221): 6e-78: 234: 71.95
+	Hs
		591482 SYTL5_HUMAN (2-412): 1.96e-92: 301: 22.17		RAB3A_HUMAN (2-192): 8.9e-57: 181: 43.98
+	Hs
		591638 SYTL5_HUMAN (2-412): 1.96e-92: 301: 22.17		RAB3B_HUMAN (2-190): 1.87e-54: 175: 43.92
+	Rn
		926103 RIMS2_RAT (3-463): 3.16e-84: 289: 14.75		RAB3A_RAT (2-192): 9.5e-57: 181: 43.98
+	Rn
		919028 RIMS2_RAT (3-463): 3.16e-84: 289: 14.75		RAB3C_RAT (2-190): 2.83e-56: 180: 43.92
+	Mm
		926097 RIMS2_MOUSE (3-463): 2.15e-81: 281: 13.83		RAB3A_MOUSE (2-192): 9.5e-57: 181: 43.98
+	Mm
		919024 RIMS2_MOUSE (3-463): 2.15e-81: 281: 13.83		RAB3C_MOUSE (2-190): 2.83e-56: 180: 43.92
+	Mm
		1321910 RIMS2_MOUSE (3-463): 2.15e-81: 281: 13.83		RAB3B_MOUSE (2-190): 3.02e-55: 177: 44.44
+	Mm
		877203 RIMS2_MOUSE (3-463): 2.15e-81: 281: 13.83		RAB8A_MOUSE (6-187): 1.15e-53: 172: 46.70