HitPredict

Interactor 1: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: JIP2 (Q9ERE9)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: Mapk8ip2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	10827173
Identification Methods	two hybrid, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4545 Mm			1 830
+	Mm
		1265300 LRP1_MOUSE (19-4545): 0: 3530: 100.00		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		69886 B1AXJ3_MOUSE (3256-3451): 4.34e-11: 71.8: 16.67		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		57562 LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		1322325 LRP1B_MOUSE (3369-3530): 9.59e-10: 67.9: 23.67		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Hs
		1032902 LRP8_HUMAN (4063-4405): 1.7e-12: 76.4: 13.26		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		957599 LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		992661 LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		992719 LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60		GULP1_HUMAN (689-820): 5.03e-42: 157: 27.82
+	Hs
		957612 LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03		ARH_HUMAN (689-815): 4.27e-39: 149: 20.16
+	Hs
		957621 LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03		ANS1B_HUMAN (563-815): 1.75e-35: 147: 18.99
+	Hs
		992682 LRP1_HUMAN (17-261): 9.34e-10: 67.9: 16.60		ANS1B_HUMAN (563-815): 1.75e-35: 147: 18.99
+	Mm
		57558 LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54		ARH_MOUSE (673-815): 3.15e-37: 144: 18.62
+	Rn
		88518 LRP2_RAT (4063-4378): 1.75e-10: 70.2: 12.57		ARH_RAT (673-815): 7.93e-35: 136: 18.62
+	Dm
		422847 NOTCH_DROME (2441-2876): 2.01e-15: 86.4: 11.47		Q9VCM6_DROME (688-815): 1.45e-24: 112: 26.92
+	Mm
		1257662 LRP4_MOUSE (4167-4500): 7.47e-13: 78: 11.78		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		69888 B1AXJ3_MOUSE (3256-3451): 4.34e-11: 71.8: 16.67		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		57563 LRP2_MOUSE (4063-4378): 2.31e-10: 69.9: 11.54		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Hs
		1048463 LRP8_HUMAN (4063-4405): 1.7e-12: 76.4: 13.26		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73
+	Mm
		1337450 LRP1B_MOUSE (3369-3530): 9.59e-10: 67.9: 23.67		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Hs
		957662 LRP2_HUMAN (27-263): 7.99e-11: 71.4: 19.03		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73