HitPredict

Interactor 1: SIGL5 (Q920G3)
Sialic acid-binding Ig-like lectin 5 (Siglec-5) (Sialic acid-binding Ig-like lectin F) (Siglec-F) (mSiglec-F) (CD antigen CD170)
Gene: Siglec5

Interactor 2: TLR1 (Q9EPQ1)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, LRR_8~V-set
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 569 Mm			1 795
+	Hs
		177599 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR1_HUMAN (4-788): 2.87e-126: 398: 73.89
+	Mm
		1265318 SIGL5_MOUSE (1-569): 8.31e-117: 359: 100.00		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Mm
		1113882 Q3Y597_MOUSE (5-243): 1.37e-90: 282: 53.09		TLR1_MOUSE (1-795): 1.38e-128: 404: 100.00
+	Hs
		177614 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR6_HUMAN (17-791): 1.13e-117: 376: 59.87
+	Mm
		1113883 Q3Y597_MOUSE (5-243): 1.37e-90: 282: 53.09		TLR6_MOUSE (16-793): 4.41e-116: 371: 65.55
+	Hs
		177605 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR10_HUMAN (5-788): 6.53e-105: 342: 46.82
+	Mm
		1144429 CD33_MOUSE (1-242): 6.23e-68: 227: 53.63		TLR1_MOUSE (1-795): 1.38e-128: 404: 100.00
+	Mm
		1113884 Q3Y597_MOUSE (5-243): 1.37e-90: 282: 53.09		TLR2_MOUSE (4-781): 3.13e-100: 329: 28.43
+	Mm
		1144428 CD33_MOUSE (1-242): 6.23e-68: 227: 53.63		TLR3_MOUSE (2-784): 1.83e-73: 259: 17.86
+	Mm
		1265316 SIGL5_MOUSE (1-569): 8.31e-117: 359: 100.00		TLR5_MOUSE (4-312): 1.89e-14: 79.6: 13.91
+	Mm
		1265317 SIGL5_MOUSE (1-569): 8.31e-117: 359: 100.00		TLR4_MOUSE (227-522): 1.37e-09: 63.8: 12.16
+	Hs
		177610 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR7_HUMAN (28-583): 4.93e-27: 120: 13.45
+	Mm
		885974 Q3Y597_MOUSE (5-243): 1.37e-90: 282: 53.09		TLR7_MOUSE (29-583): 8.71e-30: 128: 13.61
+	Hs
		177591 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR5_HUMAN (4-238): 2.74e-16: 85.4: 14.77
+	Hs
		177589 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR3_HUMAN (260-561): 8.69e-15: 80.8: 12.58
+	Hs
		120112 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR4_HUMAN (1-440): 1.1e-14: 80.4: 12.36
+	Hs
		177607 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR9_HUMAN (191-527): 6.14e-13: 75: 13.60
+	Hs
		177608 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR8_HUMAN (261-554): 1.7e-12: 73.4: 13.17
+	Hs
		177592 SIGL5_HUMAN (11-568): 1.9e-91: 293: 43.66		TLR2_HUMAN (252-531): 1.37e-09: 63.8: 12.33
+	Mm
		885976 Q3Y597_MOUSE (5-243): 1.37e-90: 282: 53.09		TLR8_MOUSE (187-640): 1.21e-10: 67.3: 13.03