HitPredict

Interactor 1: EED (Q921E6)
Polycomb protein EED
Gene: EED

Interactor 2: PRP19 (Q99KP6)
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)
Gene: Prpf19

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 441 Mm			1 504
+	Hs
		268333 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PRP19_HUMAN (1-504): 1.34e-163: 474: 99.41
+	Hs
		1281473 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		PRP19_HUMAN (1-504): 1.34e-163: 474: 99.41
+	Hs
		1288388 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		PRP19_HUMAN (1-504): 1.34e-163: 474: 99.41
+	Hs
		1281292 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		FBXW7_HUMAN (67-498): 6.11e-80: 265: 17.15
+	Hs
		1346954 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		NLE1_HUMAN (110-504): 6.21e-87: 277: 18.39
+	Hs
		1240442 POC1A_HUMAN (177-440): 1.72e-50: 177: 14.29		POC1B_HUMAN (120-365): 3.05e-49: 177: 14.82
+	Hs
		903418 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		WDR5_HUMAN (55-333): 1.74e-46: 166: 14.83
+	Dm
		1358859 FBXW7_DROME (224-441): 2.22e-25: 111: 15.53		WDS_DROME (91-337): 1.26e-47: 170: 14.73
+	Hs
		197071 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		PRP4_HUMAN (306-504): 7.64e-49: 177: 18.66
+	Dm
		1358845 WDS_DROME (267-440): 1.02e-23: 103: 15.34		WDS_DROME (91-337): 1.26e-47: 170: 14.73
+	Hs
		792935 LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69		LIS1_HUMAN (302-504): 1.44e-56: 195: 19.11
+	Mm
		925836 LIS1_MOUSE (332-438): 2.21e-14: 76.5: 18.69		LIS1_MOUSE (302-504): 1.06e-56: 195: 19.11
+	Hs
		903428 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		WDR5_HUMAN (55-333): 1.74e-46: 166: 14.83
+	Hs
		903349 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		WDR5_HUMAN (55-333): 1.74e-46: 166: 14.83
+	Hs
		209467 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		PLRG1_HUMAN (348-504): 5.39e-42: 158: 22.01
+	Hs
		903551 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		WDR5_HUMAN (55-333): 1.74e-46: 166: 14.83
+	Hs
		792949 LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69		WDR5_HUMAN (55-333): 1.74e-46: 166: 14.83
+	Hs
		1074780 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		TAF5_HUMAN (233-434): 9.56e-17: 85.5: 27.09
+	Hs
		793026 LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69		KTNB1_HUMAN (282-504): 4.14e-12: 70.5: 27.07