HitPredict

Interactor 1: EED (Q921E6)
Polycomb protein EED
Gene: EED

Interactor 2: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24457600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001739 - sex chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Mm			1 336
+	Hs
		268241 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Mm
		1206589 TBL1R_MOUSE (4-335): 1.66e-56: 196: 11.40		RING2_MOUSE (1-336): 2.13e-106: 316: 100.00
+	Hs
		1304089 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Mm
		193413 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		RING1_MOUSE (10-336): 8.61e-69: 222: 52.00
+	Hs
		268040 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		RING1_HUMAN (10-336): 3.44e-66: 215: 51.75
+	Hs
		268265 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF6_HUMAN (30-293): 1.72e-44: 157: 15.36
+	Mm
		1265430 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF6_MOUSE (31-293): 9.54e-43: 152: 16.17
+	Hs
		267917 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		BMI1_HUMAN (34-332): 2.52e-42: 151: 16.83
+	Mm
		639477 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		BMI1_MOUSE (34-332): 5.9e-42: 150: 17.16
+	Hs
		1281338 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		RING2_HUMAN (1-336): 2.74e-106: 315: 99.70
+	Hs
		267918 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF2_HUMAN (34-332): 3.57e-40: 145: 15.51
+	Mm
		1112808 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF5_MOUSE (34-334): 1.42e-40: 144: 17.59
+	Hs
		268267 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		TRI55_HUMAN (42-318): 5.67e-37: 141: 13.42
+	Mm
		620792 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF2_MOUSE (34-332): 1.26e-37: 139: 16.17
+	Hs
		267929 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		BRCA1_HUMAN (36-213): 1.88e-33: 132: 25.93
+	Hs
		268253 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF1_HUMAN (28-336): 1.37e-35: 131: 16.56
+	Mm
		1246746 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF1_MOUSE (28-336): 1.86e-34: 128: 16.24
+	Hs
		749840 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		BRCA1_HUMAN (36-213): 1.88e-33: 132: 25.93
+	Hs
		585027 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		RO52_HUMAN (36-249): 1.63e-36: 139: 13.08
+	Hs
		1019346 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		TRI26_HUMAN (36-283): 2.67e-35: 136: 17.05