Interactor 1: DYRK3 (Q922Y0)
Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1)
Gene: DYRK3
Interactor 2: SIR1 (Q923E4)
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: Sirt1
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.60 | 0.60 | 0.602 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20167603 |
| Identification Methods | two hybrid, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, protein kinase assay |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0043518 - negative regulation of DNA damage response, signal transduction by p53 class mediator |
| Homologous interactions | 11 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
