HitPredict

Interactor 1: Q923A8 (Q923A8)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25)
Gene: Map3k7

Interactor 2: JIP1 (Q9WVI9)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: Mapk8ip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	17709393
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007254 - JNK cascade
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 606 Mm			1 707
+	Mm
		1143278 M3K7_MOUSE (1-606): 0: 544: 95.55		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Hs
		201469 M3K7_HUMAN (1-606): 0: 572: 99.34		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		972470 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		1083525 M3K11_HUMAN (29-287): 5.41e-37: 149: 35.27		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		666080 FAK1_HUMAN (30-603): 4e-118: 377: 21.49		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		665145 EPHA2_HUMAN (16-358): 5.96e-100: 327: 26.67		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		666048 EPHA5_HUMAN (16-325): 5.51e-99: 326: 28.57		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		833552 EPHA5_HUMAN (16-325): 5.51e-99: 326: 28.57		NUMB_HUMAN (524-700): 2.74e-40: 159: 18.38
+	Hs
		253546 EPHA5_HUMAN (16-325): 5.51e-99: 326: 28.57		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Hs
		972457 M3K10_HUMAN (29-282): 2.43e-45: 174: 38.89		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Hs
		1032911 M3K11_HUMAN (29-287): 5.41e-37: 149: 35.27		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30