HitPredict

Interactor 1: CLC2B (Q92478)
C-type lectin domain family 2 member B (Activation-induced C-type lectin) (C-type lectin superfamily member 2) (IFN-alpha-2b-inducing-related protein 1)
Gene: CLEC2B

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	fn3~Lectin_C
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 149 Hs			1 2214
+	Hs
		1265934 CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00		SORT_HUMAN (60-756): 7.38e-180: 572: 28.88
+	Hs
		59752 KLRG2_HUMAN (2-146): 5.17e-35: 126: 26.32		PTPRS_HUMAN (1571-2022): 3.54e-53: 209: 19.15
+	Hs
		149944 NCAN_HUMAN (8-146): 1.55e-45: 160: 19.21		PTPRF_HUMAN (1575-1852): 4.84e-34: 146: 15.66
+	Hs
		489893 CSPG2_HUMAN (8-146): 6.11e-44: 155: 21.85		PTPRF_HUMAN (1575-1852): 4.84e-34: 146: 15.66
+	Hs
		490037 CLC4A_HUMAN (16-147): 7.74e-35: 122: 23.13		PTPRF_HUMAN (1575-1852): 4.84e-34: 146: 15.66
+	Hs
		149947 NCAN_HUMAN (8-146): 1.55e-45: 160: 19.21		TENA_HUMAN (1661-1934): 2.12e-13: 78.5: 13.04
+	Rn
		70327 G3V8R2_RAT (8-146): 3.25e-46: 162: 20.53		B2LYI9_RAT (978-1118): 3.01e-09: 65: 15.03
+	Hs
		270317 CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00		LRP6_HUMAN (1445-1549): 6.8e-11: 70.1: 36.94
+	Hs
		258336 CLC2B_HUMAN (1-149): 1.2e-43: 142: 100.00		LRP5_HUMAN (1445-1549): 8.69e-11: 69.7: 37.27