HitPredict

Interactor 1: LRP8 (Q924X6)
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Gene: LRP8

Interactor 2: JIP2 (Q9ERE9)
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Gene: Mapk8ip2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	10827173
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019894 - kinesin binding GO:0043025 - neuronal cell body GO:0048813 - dendrite morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 996 Mm			1 830
+	Mm
		1266182 LRP8_MOUSE (1-996): 0: 810: 100.00		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		69886 B1AXJ3_MOUSE (4-161): 1.48e-12: 73.7: 16.67		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		57562 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Mm
		1322325 LRP1B_MOUSE (35-190): 5.05e-09: 62.9: 19.51		JIP2_MOUSE (1-830): 1.18e-174: 526: 100.00
+	Hs
		1032902 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		992661 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		957599 LRP2_HUMAN (725-932): 4.49e-09: 62.9: 11.81		JIP2_HUMAN (1-830): 5.03e-144: 446: 84.51
+	Hs
		351073 LDLR_HUMAN (4-329): 9.79e-37: 151: 28.06		ARH_HUMAN (689-815): 4.27e-39: 149: 20.16
+	Hs
		992719 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		GULP1_HUMAN (689-820): 5.03e-42: 157: 27.82
+	Hs
		957612 LRP2_HUMAN (725-932): 4.49e-09: 62.9: 11.81		ARH_HUMAN (689-815): 4.27e-39: 149: 20.16
+	Hs
		992682 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		ANS1B_HUMAN (563-815): 1.75e-35: 147: 18.99
+	Hs
		957621 LRP2_HUMAN (725-932): 4.49e-09: 62.9: 11.81		ANS1B_HUMAN (563-815): 1.75e-35: 147: 18.99
+	Mm
		57558 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		ARH_MOUSE (673-815): 3.15e-37: 144: 18.62
+	Mm
		1257662 LRP4_MOUSE (6-248): 3.06e-28: 125: 19.79		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Rn
		88518 LRP2_RAT (724-932): 3.05e-09: 63.7: 12.19		ARH_RAT (673-815): 7.93e-35: 136: 18.62
+	Hs
		1048463 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73
+	Mm
		69888 B1AXJ3_MOUSE (4-161): 1.48e-12: 73.7: 16.67		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		57563 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Mm
		1337450 LRP1B_MOUSE (35-190): 5.05e-09: 62.9: 19.51		JIP1_MOUSE (13-349): 1.11e-15: 83.3: 22.35
+	Hs
		992729 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		JIP1_HUMAN (13-349): 1.7e-13: 76.3: 22.73