HitPredict

Interactor 1: LRP8 (Q924X6)
Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)
Gene: LRP8

Interactor 2: JIP1 (Q9WVI9)
C-Jun-amino-terminal kinase-interacting protein 1 (JIP-1) (JNK-interacting protein 1) (Islet-brain-1) (IB-1) (JNK MAP kinase scaffold protein 1) (Mitogen-activated protein kinase 8-interacting protein 1)
Gene: Mapk8ip1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	10827173
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0019894 - kinesin binding GO:0030424 - axon GO:0030425 - dendrite GO:0043025 - neuronal cell body and 1 others more... GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 996 Mm			1 707
+	Mm
		1266181 LRP8_MOUSE (1-996): 0: 810: 100.00		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Mm
		1257662 LRP4_MOUSE (6-248): 3.06e-28: 125: 19.79		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		69888 B1AXJ3_MOUSE (4-161): 1.48e-12: 73.7: 16.67		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Mm
		57563 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		JIP1_MOUSE (1-707): 0: 783: 100.00
+	Hs
		1048463 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		992729 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		JIP1_HUMAN (1-707): 0: 730: 92.42
+	Hs
		970699 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		APBA1_HUMAN (70-698): 4.28e-126: 396: 16.54
+	Hs
		351073 LDLR_HUMAN (4-329): 9.79e-37: 151: 28.06		ARH_HUMAN (543-702): 9.88e-38: 144: 19.14
+	Hs
		992682 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		ANS1B_HUMAN (419-696): 2.27e-61: 225: 18.51
+	Hs
		1032902 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Hs
		351135 EGF_HUMAN (302-444): 5.81e-10: 65.6: 13.53		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		666087 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		SHC1_HUMAN (413-696): 5.55e-57: 205: 15.02
+	Hs
		253558 LRP8_HUMAN (4-266): 2.83e-24: 111: 28.26		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Mm
		69886 B1AXJ3_MOUSE (4-161): 1.48e-12: 73.7: 16.67		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Hs
		992719 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		GULP1_HUMAN (537-697): 3.87e-49: 176: 29.63
+	Mm
		57562 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		JIP2_MOUSE (21-256): 1e-44: 174: 29.46
+	Hs
		992661 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		JIP2_HUMAN (21-266): 8.52e-45: 174: 32.30
+	Hs
		253555 LRP1_HUMAN (62-337): 2.4e-09: 63.7: 14.19		CAPON_HUMAN (541-703): 1.09e-36: 146: 20.69
+	Mm
		57558 LRP2_MOUSE (716-932): 1.76e-09: 64.5: 13.55		ARH_MOUSE (527-692): 5.9e-37: 142: 17.54
+	Rn
		88518 LRP2_RAT (724-932): 3.05e-09: 63.7: 12.19		ARH_RAT (527-692): 2.01e-34: 135: 17.54