HitPredict

Interactor 1: TRIB2 (Q92519)
Tribbles homolog 2 (TRB-2)
Gene: TRIB2

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	25311538, 23769673, 24211582
Identification Methods	affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 343 Hs			1 605
+	Hs
		682082 AKT1_HUMAN (9-342): 2.12e-135: 395: 20.63		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		568836 KAPCA_HUMAN (50-343): 2.9e-130: 377: 20.46		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		568826 KAPCA_HUMAN (50-343): 2.9e-130: 377: 20.46		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		681967 AKT1_HUMAN (9-342): 2.12e-135: 395: 20.63		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Dm
		1213409 AKT1_DROME (5-342): 4e-132: 391: 16.90		NLE_DROME (218-531): 8.76e-63: 216: 20.22
+	Dm
		218248 AKT1_DROME (5-342): 4e-132: 391: 16.90		O44382_DROME (466-605): 2.38e-30: 127: 29.37
+	Dm
		1213390 AKT1_DROME (5-342): 4e-132: 391: 16.90		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37