HitPredict - High confidence protein-protein interactions

Interactor 1: NICA (Q92542)
Nicastrin
Gene: NCSTN

Interactor 2: PEN2 (Q9NZ42)
Gamma-secretase subunit PEN-2 (Presenilin enhancer protein 2)
Gene: PSENEN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	18667537, 14572442, 22074918, 12198112, 15322109, 18201567
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ncstrn_small~PEN-2
Common GO terms	GO:0000139 - Golgi membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane and 14 others more... GO:0006509 - membrane protein ectodomain proteolysis GO:0007219 - Notch signaling pathway GO:0007220 - Notch receptor processing GO:0010008 - endosome membrane GO:0010950 - positive regulation of endopeptidase activity GO:0016020 - membrane GO:0016485 - protein processing GO:0031293 - membrane protein intracellular domain proteolysis GO:0034205 - amyloid-beta formation GO:0042734 - presynaptic membrane GO:0042982 - amyloid precursor protein metabolic process GO:0042987 - amyloid precursor protein catabolic process GO:0043085 - positive regulation of catalytic activity GO:0070765 - gamma-secretase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	709
Hs

1	101

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024