HitPredict

Interactor 1: ELMO1 (Q92556)
Engulfment and cell motility protein 1 (Protein ced-12 homolog)
Gene: ELMO1

Interactor 2: DOCK5 (Q9H7D0)
Dedicator of cytokinesis protein 5
Gene: DOCK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	32203420, 26186194, 21930703, 28514442, 33961781, unassigned2213
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	DOCK_N~PH_12
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016601 - Rac protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 727 Hs			1 1870
+	Mm
		1207128 ELMO1_MOUSE (1-727): 0: 1065: 99.59		DOCK1_MOUSE (1-1824): 0: 1945: 64.15
+	Hs
		1050484 ELMO1_HUMAN (1-727): 0: 1066: 100.00		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		1295265 ELMO2_HUMAN (1-724): 0: 983: 75.59		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Mm
		1207130 ELMO1_MOUSE (1-727): 0: 1065: 99.59		DOCK2_MOUSE (1-1825): 0: 1875: 55.00
+	Hs
		1285559 ELMO3_HUMAN (1-727): 0: 932: 51.51		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Mm
		1206593 ELMO2_MOUSE (1-724): 0: 973: 74.22		DOCK1_MOUSE (1-1824): 0: 1945: 64.15
+	Hs
		1267020 ELMO1_HUMAN (1-727): 0: 1066: 100.00		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		1050489 ELMO2_HUMAN (1-724): 0: 983: 75.59		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Mm
		1207312 ELMO3_MOUSE (1-725): 0: 924: 52.47		DOCK1_MOUSE (1-1824): 0: 1945: 64.15
+	Hs
		1050487 ELMO3_HUMAN (1-727): 0: 932: 51.51		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		1267934 ELMO2_HUMAN (1-724): 0: 983: 75.59		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		1224220 ELMO1_HUMAN (1-727): 0: 1066: 100.00		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		1230987 ELMO1_HUMAN (1-727): 0: 1066: 100.00		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Hs
		1224227 ELMO2_HUMAN (1-724): 0: 983: 75.59		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		1230992 ELMO2_HUMAN (1-724): 0: 983: 75.59		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Hs
		1061751 ELMO2_HUMAN (1-724): 0: 983: 75.59		Q149N5_HUMAN (4-1867): 0: 1661: 33.74
+	Hs
		1224225 ELMO3_HUMAN (1-727): 0: 932: 51.51		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		1230990 ELMO3_HUMAN (1-727): 0: 932: 51.51		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Dm
		1362934 Q9VKB2_DROME (5-725): 0: 834: 45.79		Q9VCH4_DROME (1-1821): 0: 1698: 36.40
+	Dm
		81396 Q9VKB2_DROME (5-725): 0: 834: 45.79		B7Z0R2_DROME (4-1810): 0: 1566: 34.47