HitPredict

Interactor 1: WASF1 (Q92558)
Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)
Gene: WASF1

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030027 - lamellipodium GO:0030036 - actin cytoskeleton organization GO:0031209 - SCAR complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 559 Hs			1 366
+	Rn
		1124757 WASF1_RAT (1-559): 1.61e-69: 235: 97.50		ABI1_RAT (1-314): 2.45e-66: 219: 34.88
+	Mm
		1206472 WASF2_MOUSE (1-374): 2.98e-111: 342: 46.19		ABI1_MOUSE (272-363): 1.7e-21: 97.4: 44.57
+	Hs
		1350207 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		1267032 WASF1_HUMAN (1-559): 2.63e-73: 245: 100.00		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		1224624 WASF1_HUMAN (1-559): 2.63e-73: 245: 100.00		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		924734 WASF1_HUMAN (1-559): 2.63e-73: 245: 100.00		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		1052366 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		SRC8_HUMAN (40-363): 2.07e-42: 157: 16.12
+	Dm
		94643 F2FB81_DROME (1-542): 1.87e-49: 183: 23.93		DBNL_DROME (17-363): 3.62e-33: 131: 15.05
+	Dm
		94647 F2FB81_DROME (1-542): 1.87e-49: 183: 23.93		Q9Y0S9_DROME (260-364): 1.16e-20: 94.7: 38.32
+	Hs
		1348432 WASF3_HUMAN (1-557): 1.12e-43: 164: 45.73		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		1348444 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		ABI2_HUMAN (109-363): 4.36e-25: 108: 23.18
+	Hs
		1224659 WASF3_HUMAN (1-557): 1.12e-43: 164: 45.73		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		1224667 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Dd
		1122140 SCAR_DICDI (24-358): 7.66e-34: 135: 20.77		ABIA_DICDI (3-321): 6.97e-30: 119: 19.32
+	Rn
		192354 SYNJ1_RAT (123-554): 5.15e-35: 142: 12.99		SH3G2_RAT (265-363): 2.5e-26: 109: 23.76
+	Hs
		1349289 WASF2_HUMAN (1-541): 2.37e-42: 160: 42.14		ITSN2_HUMAN (306-365): 5.38e-13: 72.7: 37.50
+	Hs
		166042 SYNJ2_HUMAN (46-507): 2.06e-31: 132: 13.92		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		166056 SYNJ2_HUMAN (46-507): 2.06e-31: 132: 13.92		ITSN2_HUMAN (306-365): 5.38e-13: 72.7: 37.50
+	Hs
		924521 EP300_HUMAN (77-554): 1.1e-28: 124: 14.91		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		166049 SYNJ2_HUMAN (46-507): 2.06e-31: 132: 13.92		ITSN1_HUMAN (205-363): 8.02e-10: 62.8: 15.85