HitPredict

Interactor 1: BAP1 (Q92560)
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)
Gene: BAP1

Interactor 2: ASXL3 (Q9C0F0)
Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3)
Gene: ASXL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26647312, 33961781, 32669118
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ASXH~Peptidase_C12, ASXH~UCH_C
Common GO terms	GO:0003682 - chromatin binding GO:0035517 - PR-DUB complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 729 Hs			1 2248
+	Hs
		1176250 BAP1_HUMAN (1-729): 0: 1185: 100.00		ASXL2_HUMAN (1196-2248): 2.48e-54: 212: 12.78
+	Hs
		1220793 BAP1_HUMAN (1-729): 0: 1185: 100.00		ASXL1_HUMAN (1104-2248): 2.83e-43: 176: 13.52
+	Mm
		1207491 BAP1_MOUSE (1-729): 0: 1120: 93.14		ASXL2_MOUSE (1-1405): 5.89e-55: 214: 18.99
+	Hs
		1264772 BAP1_HUMAN (1-729): 0: 1185: 100.00		TITIN_HUMAN (201-2031): 7.33e-34: 146: 8.37
+	Mm
		886980 BAP1_MOUSE (1-729): 0: 1120: 93.14		ASXL1_MOUSE (1141-2248): 4.6e-50: 198: 15.07
+	Hs
		1267264 BAP1_HUMAN (1-729): 0: 1185: 100.00		SRRM2_HUMAN (548-2180): 2.16e-27: 125: 10.23
+	Hs
		257673 BAP1_HUMAN (1-729): 0: 1185: 100.00		ANR17_HUMAN (345-1422): 1.78e-26: 121: 11.40
+	Hs
		807789 BAP1_HUMAN (1-729): 0: 1185: 100.00		MAP1B_HUMAN (48-1352): 3.59e-18: 94.2: 9.02
+	Hs
		1186076 BAP1_HUMAN (1-729): 0: 1185: 100.00		MICA3_HUMAN (362-1065): 6.25e-15: 83.5: 15.40
+	Dm
		1180430 CALYP_DROME (617-712): 1.15e-39: 154: 43.14		ASX_DROME (2168-2246): 2.52e-15: 85.1: 36.15