HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: HOOK2 (Q96ED9)
Protein Hook homolog 2 (h-hook2) (hHK2)
Gene: HOOK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1164 Hs			1 719
+	Hs
		61869 TSC1_HUMAN (1-1164): 0: 725: 100.00		CC88B_HUMAN (68-410): 7.29e-22: 103: 23.94
+	Hs
		1051301 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		GRDN_HUMAN (37-565): 6.81e-15: 81.3: 14.55
+	Hs
		1051348 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		HOOK3_HUMAN (240-711): 2.67e-12: 72.4: 15.04
+	Hs
		1051492 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		DAPLE_HUMAN (253-718): 2.4e-10: 66.4: 16.49
+	Hs
		1051504 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		HOOK1_HUMAN (328-719): 5.67e-10: 64.7: 11.88
+	Rn
		655923 DCTN1_RAT (540-1022): 4.75e-54: 209: 16.13		DCTN1_RAT (165-514): 2.79e-09: 62.6: 17.47
+	Hs
		1268126 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MRCKB_HUMAN (161-638): 1.26e-20: 99.6: 15.68
+	Hs
		725097 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		MYH10_HUMAN (368-719): 1.25e-16: 86.7: 11.62
+	Hs
		148466 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		MYH11_HUMAN (4-553): 8.3e-21: 100: 11.90
+	Hs
		528395 CACO1_HUMAN (620-1116): 8.08e-29: 126: 14.93		MYH6_HUMAN (350-719): 1.44e-13: 77: 10.27
+	Bt
		1100183 ROCK2_BOVIN (323-1080): 4.41e-28: 125: 9.38		ROCK2_BOVIN (150-659): 2.53e-13: 76.1: 15.21
+	Hs
		724943 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MYH9_HUMAN (347-719): 2.16e-16: 85.9: 10.72
+	Hs
		724687 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH10_HUMAN (368-719): 1.25e-16: 86.7: 11.62
+	Hs
		724686 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH9_HUMAN (347-719): 2.16e-16: 85.9: 10.72
+	Hs
		148461 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		MYH10_HUMAN (368-719): 1.25e-16: 86.7: 11.62
+	Hs
		148460 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		MYH9_HUMAN (347-719): 2.16e-16: 85.9: 10.72
+	Hs
		1268099 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MYO5C_HUMAN (162-651): 1.38e-13: 76.9: 16.44
+	Hs
		725035 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYO5C_HUMAN (162-651): 1.38e-13: 76.9: 16.44
+	Hs
		149399 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		HOOK1_HUMAN (328-719): 5.67e-10: 64.7: 11.88
+	Hs
		148359 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		DESP_HUMAN (181-664): 2.01e-09: 63.4: 13.06