HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: HSH2D (Q96JZ2)
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
Gene: HSH2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1164 Hs			1 352
+	Hs
		1267550 TSC1_HUMAN (1-1164): 0: 725: 100.00		SH22A_HUMAN (17-212): 4.9e-39: 144: 29.35
+	Hs
		924566 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		412287 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		412058 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		111443 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		J3QRU1_HUMAN (2-181): 3.53e-38: 144: 17.07
+	Hs
		433272 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		YES_HUMAN (2-181): 3.84e-38: 144: 17.07
+	Hs
		411983 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		FYN_HUMAN (3-207): 5.32e-40: 149: 16.81
+	Hs
		728465 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		924736 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		411581 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		724756 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		523231 MYH4_HUMAN (393-969): 2.58e-19: 96.8: 11.22		SRC_HUMAN (2-207): 1.8e-36: 139: 17.37
+	Dm
		113911 MYSN_DROME (417-1038): 2.47e-19: 96.8: 9.88		M9PAY7_DROME (19-194): 4.5e-36: 131: 19.23
+	Hs
		411758 MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		551599 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		NCK1_HUMAN (1-121): 6.52e-31: 122: 28.46
+	Hs
		411908 MRCKB_HUMAN (835-1162): 1.41e-15: 84.5: 6.67		LCK_HUMAN (2-207): 1.04e-35: 137: 19.57
+	Hs
		924622 CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		924666 MYH14_HUMAN (620-918): 1.78e-11: 71.1: 13.11		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66
+	Hs
		725134 MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43		GRB2_HUMAN (14-150): 1.34e-34: 127: 24.66