HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: SPAG5 (Q96R06)
Sperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Gene: SPAG5

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21653829
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1164 Hs			1 1193
+	Hs
		1051420 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		SPAG5_HUMAN (1-1193): 4.62e-140: 457: 100.00
+	Hs
		148801 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Bt
		1100183 ROCK2_BOVIN (323-1080): 4.41e-28: 125: 9.38		ROCK2_BOVIN (713-1193): 4.55e-15: 82.7: 12.55
+	Hs
		254476 ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27		ROCK1_HUMAN (546-1186): 1.44e-17: 90.8: 14.97
+	Hs
		724810 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		ROCK1_HUMAN (546-1186): 1.44e-17: 90.8: 14.97
+	Hs
		1268060 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MY18A_HUMAN (692-1192): 6.2e-16: 85.8: 13.78
+	Hs
		725097 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Rn
		92843 CTRO_RAT (337-1025): 8.64e-25: 114: 9.83		ROCK2_RAT (674-1191): 5.21e-15: 82.7: 11.69
+	Hs
		148466 MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		528395 CACO1_HUMAN (620-1116): 8.08e-29: 126: 14.93		MYH6_HUMAN (958-1190): 3.59e-09: 63.7: 14.16
+	Hs
		1068617 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		724895 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH14_HUMAN (449-1088): 6.07e-13: 75.8: 14.74
+	Hs
		724943 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		724839 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		PLEC_HUMAN (462-1139): 9.56e-12: 72: 14.40
+	Hs
		149126 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		724687 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH10_HUMAN (837-1188): 2.71e-11: 70.7: 11.33
+	Hs
		724686 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		MYH9_HUMAN (873-1192): 7.59e-11: 69.1: 13.04
+	Hs
		148460 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51
+	Hs
		148126 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		CTRO_HUMAN (356-721): 3.32e-10: 66.9: 9.51