HitPredict

Interactor 1: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1164 Hs			1 1088
+	Hs
		681956 TSC1_HUMAN (1-1164): 0: 725: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		682126 TSC1_MOUSE (1-1164): 0: 695: 86.98		AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16
+	Hs
		149340 CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1073456 TSC1_HUMAN (1-1164): 0: 725: 100.00		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		325608 MYH1_HUMAN (393-967): 5.76e-21: 102: 11.23		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		681840 DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		725079 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		ST38L_HUMAN (592-1051): 1.3e-146: 448: 41.30
+	Dm
		1213452 Q8INC3_DROME (441-1011): 3.85e-23: 109: 11.72		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Dm
		1001877 Q0KI67_DROME (441-1011): 8.87e-23: 107: 11.72		WARTS_DROME (167-1039): 7.21e-137: 443: 39.71
+	Hs
		681696 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		551616 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		724784 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		568567 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		551672 DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		116964 MYH1_HUMAN (393-967): 5.76e-21: 102: 11.23		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		254459 ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		1268126 MY18A_HUMAN (461-1064): 4e-25: 115: 10.31		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Bt
		1100183 ROCK2_BOVIN (323-1080): 4.41e-28: 125: 9.38		ROCK2_BOVIN (640-1008): 6.44e-67: 248: 37.17
+	Hs
		254476 ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77
+	Hs
		724810 MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40		ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77