HitPredict

Interactor 1: GCN1 (Q92616)
Stalled ribosome sensor GCN1 (GCN1 eIF-2-alpha kinase activator homolog) (GCN1-like protein 1) (General control of amino-acid synthesis 1-like protein 1) (Translational activator GCN1) (HsGCN1)
Gene: GCN1

Interactor 2: PD1L1 (Q9NZQ7)
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (hPD-L1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene: CD274

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.50	0.599

Property	Details
Experiments	26186194, 28514442, 36376293
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2671 Hs			1 290
+	Hs
		1117742 Q4LE60_HUMAN (1189-2014): 7.32e-59: 225: 12.28		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		1273232 TNPO1_HUMAN (908-1705): 1.2e-50: 198: 13.59		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		1117739 Q4LE60_HUMAN (1189-2014): 7.32e-59: 225: 12.28		VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11
+	Hs
		1166522 TNPO1_HUMAN (908-1705): 1.2e-50: 198: 13.59		BTNL9_HUMAN (14-289): 1.23e-48: 171: 14.44
+	Hs
		127391 IPO5_HUMAN (1381-2409): 4.59e-37: 155: 12.18		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		787589 MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		1273203 TNPO1_HUMAN (908-1705): 1.2e-50: 198: 13.59		VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11
+	Hs
		1202158 CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		787545 MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46		VSIG2_HUMAN (3-270): 3.76e-40: 144: 15.11
+	Hs
		1047830 CKAP5_HUMAN (953-1968): 8.99e-11: 70.1: 10.33		PD1L1_HUMAN (1-290): 1.08e-62: 201: 100.00
+	Hs
		706885 MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46		CD80_HUMAN (28-259): 6.01e-30: 116: 21.07
+	Hs
		130188 CKAP5_HUMAN (953-1968): 8.99e-11: 70.1: 10.33		BT3A3_HUMAN (3-289): 7.81e-46: 164: 18.52
+	Hs
		1166655 CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92		LRIG3_HUMAN (19-236): 1.66e-26: 111: 13.70
+	Hs
		787412 MTOR_HUMAN (824-2632): 3.31e-34: 147: 12.46		MUC18_HUMAN (20-245): 2.36e-12: 69.1: 17.17
+	Hs
		793376 CAND1_HUMAN (1460-2587): 2.11e-22: 108: 13.92		MUC18_HUMAN (20-245): 2.36e-12: 69.1: 17.17