HitPredict

Interactor 1: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Interactor 2: DCAF5 (Q96JK2)
DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)
Gene: DCAF5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	19287380, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 601 Hs			1 942
+	Hs
		1044053 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		DCAF5_HUMAN (1-942): 0: 784: 99.15
+	Hs
		1268574 DYRK2_HUMAN (1-601): 0: 534: 100.00		FBXW7_HUMAN (1-303): 8.46e-68: 242: 17.38
+	Hs
		625543 CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71		FBXW7_HUMAN (1-303): 8.46e-68: 242: 17.38
+	Hs
		929595 DYRK2_HUMAN (1-601): 0: 534: 100.00		RACK1_HUMAN (272-550): 2.02e-28: 118: 9.18
+	Mm
		554925 KPCE_MOUSE (55-510): 2.32e-124: 385: 16.70		FBXW7_MOUSE (1-303): 1.53e-67: 241: 17.05
+	Hs
		415016 CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13		FBXW7_HUMAN (1-303): 8.46e-68: 242: 17.38
+	Hs
		1044022 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		FBXW7_HUMAN (1-303): 8.46e-68: 242: 17.38
+	Hs
		903402 DYRK2_HUMAN (1-601): 0: 534: 100.00		WDR5_HUMAN (1-84): 3.55e-11: 67.6: 15.12
+	Hs
		1319415 DYRK4_HUMAN (119-595): 5.24e-124: 377: 44.24		WDR33_HUMAN (1-215): 5.3e-45: 178: 17.35
+	Hs
		625202 CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71		LIS1_HUMAN (266-571): 7.71e-32: 131: 11.04
+	Hs
		625337 CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71		RACK1_HUMAN (272-550): 2.02e-28: 118: 9.18
+	Hs
		414806 CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13		LIS1_HUMAN (266-571): 7.71e-32: 131: 11.04
+	Hs
		929405 KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70		RACK1_HUMAN (272-550): 2.02e-28: 118: 9.18
+	Sc
		565470 PHO85_YEAST (220-543): 3.63e-117: 352: 26.35		NLE1_YEAST (278-549): 4.31e-34: 139: 13.62
+	Dm
		1213409 AKT1_DROME (6-510): 1.51e-116: 361: 16.32		NLE_DROME (266-581): 1.99e-29: 125: 12.99
+	Hs
		1281385 HIPK2_HUMAN (205-535): 2.73e-52: 195: 34.94		FBXW7_HUMAN (1-303): 8.46e-68: 242: 17.38
+	Mm
		829607 CDK5_MOUSE (219-541): 4.27e-119: 356: 28.10		WDTC1_MOUSE (46-218): 5.24e-14: 78.2: 32.04
+	Hs
		833971 CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56		WDR33_HUMAN (1-215): 5.3e-45: 178: 17.35