HitPredict

Interactor 1: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1990904 - ribonucleoprotein complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 601 Hs			1 482
+	Hs
		625639 CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1044271 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		414901 CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		414930 CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		414914 CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		1043815 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43
+	Hs
		1043783 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69
+	Hs
		1044050 DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52		CELF6_HUMAN (287-416): 2.28e-15: 80.3: 16.54
+	Sc
		565521 PHO85_YEAST (220-543): 3.63e-117: 352: 26.35		NTF2_YEAST (10-132): 1.12e-20: 89.2: 28.80
+	Hs
		833740 CLK1_HUMAN (204-535): 3.1e-62: 215: 35.80		SAFB1_HUMAN (141-482): 2.07e-42: 163: 16.43