HitPredict

Interactor 1: LPAR1 (Q92633)
Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2)
Gene: LPAR1

Interactor 2: AGRL3 (Q9HAR2)
Adhesion G protein-coupled receptor L3 (Calcium-independent alpha-latrotoxin receptor 3) (CIRL-3) (Latrophilin-3) (Lectomedin-3)
Gene: ADGRL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004930 - G protein-coupled receptor activity GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 1447
+	Hs
		328394 S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89		CELR2_HUMAN (392-1314): 0: 645: 22.70
+	Hs
		823075 LPAR1_HUMAN (1-364): 3.44e-73: 233: 100.00		AGRE5_HUMAN (396-1152): 6.22e-170: 532: 25.80
+	Hs
		328313 S1PR4_HUMAN (1-360): 9.27e-72: 230: 30.89		AGRE5_HUMAN (396-1152): 6.22e-170: 532: 25.80
+	Hs
		1268681 LPAR1_HUMAN (1-364): 3.44e-73: 233: 100.00		AGRE2_HUMAN (396-1146): 4.8e-165: 519: 24.81
+	Hs
		722942 ADA1A_HUMAN (28-340): 4.04e-65: 215: 17.09		AGRA3_HUMAN (449-1362): 3.64e-127: 430: 16.38
+	Hs
		1197861 LPAR1_HUMAN (1-364): 3.44e-73: 233: 100.00		AGRG6_HUMAN (501-1136): 1.03e-118: 404: 24.81
+	Hs
		429162 ADRB2_HUMAN (54-350): 1.7e-66: 217: 17.38		AGRG1_HUMAN (555-1109): 7.13e-109: 363: 21.05