HitPredict

Interactor 1: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Interactor 2: GGA2 (Q9UJY4)
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Gene: GGA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	30679749, 11821067, 32814053
Identification Methods	two hybrid, pull down, validated two hybrid, two hybrid array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0010008 - endosome membrane GO:0031267 - small GTPase binding GO:0031901 - early endosome membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2214 Hs			1 613
+	Mm
		291365 SORL_MOUSE (1-2214): 0: 1915: 93.18		GGA2_MOUSE (11-613): 9.13e-178: 518: 84.74
+	Hs
		1269037 SORL_HUMAN (1-2214): 0: 1927: 100.00		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		1304358 SORT_HUMAN (60-756): 7.38e-180: 572: 28.88		GGA2_HUMAN (12-613): 0: 556: 100.00
+	Hs
		1304359 SORT_HUMAN (60-756): 7.38e-180: 572: 28.88		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		1270609 SORT_HUMAN (60-756): 7.38e-180: 572: 28.88		STAM1_HUMAN (19-524): 3.22e-96: 306: 15.76
+	Hs
		1304348 SORT_HUMAN (60-756): 7.38e-180: 572: 28.88		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Sc
		687096 VPS10_YEAST (123-828): 4.62e-80: 296: 17.44		GGA2_YEAST (15-607): 3.14e-107: 336: 19.31
+	Hs
		1048460 LRP8_HUMAN (1323-1699): 1.23e-19: 98.5: 19.36		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67